DNA Methylation Manel Esteller

ISBN: 9781402036422

Published: January 1st 2005

ebook

310 pages


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DNA Methylation  by  Manel Esteller

DNA Methylation by Manel Esteller
January 1st 2005 | ebook | PDF, EPUB, FB2, DjVu, AUDIO, mp3, ZIP | 310 pages | ISBN: 9781402036422 | 8.56 Mb

A broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in theMoreA broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour.

It also provides a comprehensive insightful look at the molecular players involved the DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally, it explains how epeigenetic lesions associated with cancer spreading can be targeted using new and potent chemotherapy drugs. The book is a state-of-the-art reference to all scientific researchers and clinicians interested in the understanding of the biological processes leading to tumor dissemination and to those that are keen to translate this knowledge to a better management of cancer patients.

Each contributor is a specialist in their epigenetic area and their joint effort has created a unique view of the DNA methylation, histone and chromatin changes that define cancer metastasis.



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