Gap Junctions in Development and Disease Elke Winterhager

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Published: August 1st 2005

Kindle Edition

279 pages


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Gap Junctions in Development and Disease  by  Elke Winterhager

Gap Junctions in Development and Disease by Elke Winterhager
August 1st 2005 | Kindle Edition | PDF, EPUB, FB2, DjVu, audiobook, mp3, RTF | 279 pages | ISBN: | 10.60 Mb

Communication between cells via intercellular channels – gap junctions – appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlyingMoreCommunication between cells via intercellular channels – gap junctions – appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility.

Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed.Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.



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